Table 2.

Association between serum IL8 levels with the risk of first CVE and CVD related death expressed as hazard ratios (HR), 95% confidence intervals (CI)

	IL8Q1	IL8Q2	p	IL8Q3	p	IL8Q4	p
CVE (n = 522)	776/125	782/127		776/128		765/142
Crude (n = 3626)	1	1.01 (0.78–1.29)	0.94	1.03 (0.80–1.31)	0.81	1.15 (0.90–1.46)	0.24
Model 1 (n = 3583)	1	0.98 (0.76–1.25)	0.87	0.94 (0.73–1.20)	0.63	0.96 (0.75–1.22)	0.74
MI and angina requiring hospitalization (n = 358)	778/91	783/82		779/94		764/91
Crude (n = 3462)	1	0.90 (0.67–1.21)	0.51	1.03 (0.78–1.38)	0.80	1.03 (0.77–1.38)	0.82
Model 1 (n = 3417)	1	0.88 (0.65–1.20)	0.44	0.93 (0.70–1.24)	0.63	0.83 (0.62–1.24)	0.23
Ischemic stroke (n = 164)	778/34	783/45		779/33		764/52
Crude (n = 3462)	1	1.30 (0.83–2.03)	0.24	0.97 (0.60–1.57)	0.91	1.55 (1.01–2.40)	0.04
Model 1 (n = 3226)	1	1.24 (0.79–1.94)	0.34	0.91 (0.56–1.48)	0.73	1.37 (0.88–2.12)	0.15

Number of study participants in each IL8 quartile refers to the crude model. Ischemic stroke cases (n = 164) were excluded from the analysis of the association of IL8 with the risk of MI and angina requiring hospitalization. MI and angina requiring hospitalization (n = 358) were excluded from the analysis of the association of IL8 with the risk of ischemic stroke. Missing values in the confounders are specified in Table 1

Model 1: adjusted by sex, smoking, diabetes, hypercholesterolemia, hypertension, diabetes and central obesity