Table 3.

Association between serum IL8 levels and risk of all cause, CVD and cancer related mortality expressed as hazard ratios (HR), 95% confidence intervals (CI)

	IL8Q1	IL8Q2	p	IL8Q3	p	IL8Q4	p
All-cause mortality (n = 647)	869/127	849/153		843/178		803/189
Crude (n = 4011)	1	1.21 (0.95–1.53)	0.11	1.40 (1.11–1.76)	0.004	1.54 (1.23–1.93)	< 0.0001
Model 1a (n = 3845)	1	1.13 (0.89–1.45)	0.30	1.34 (1.06–1.70)	0.01	1.35 (1.07–1.71)	0.01
Model 1b (n = 3837)	1	1.09 (0.85–1.39)	0.38	1.27 (1.01–1.62)	0.04	1.28 (1.02–1.63)	0.03
CVD related mortality (n = 136)	885/24	881/38		878/32		868/42
Crude (n = 3648)	1	1.58 (0.95–2.64)	0.07	1.35 (0.79–2.29)	0.26	1.80 (1.01–2.97)	0.02
Model 1a (n = 3509)	1	1.48 (0.80–2.32)	0.15	1.35 (0.77–2.36)	0.28	1.48 (0.87–2.53)	0.14
Model 1b (n = 3504)	1	1.37 (0.79–2.38)	0.25	1.24 (0.71–2.17)	0.44	1.35 (0.79–2.32)	0.26
Cancer related mortality (n = 266)	906/55	903/68		934/64		887/79
Crude (n = 3896)	1	1.23 (0.89–1.78)	0.18	1.15 (0.80–1.65)	0.44	1.46 (1.04–2.07)	0.03
Model 1a (n = 3732)	1	1.18 (0.82–1.71)	0.36	1.09 (0.75–1.59)	0.62	1.27 (0.89–1.82)	0.18
Model 1b (n = 3724)	1	1.15 (0.79–1.66)	0.45	1.06 (0.73–1.53)	0.75	1.23 (0.86–1.77)	0.24

Numbers of study participants is reported for the crude model. Missing values in the confounders are specified in Table 1. Model 1a: adjusted by sex, smoking, alcohol consumption, physical activity at work and during leisure time; Model 1b: model 1a + systolic and diastolic blood pressure, central obesity, cholesterol and glucose levels