Table 5.
Projected costs and epidemiologic outcomes over 20 years
| Outcomes per 1000 persons | Cost (95% UR) | TB incidence (95% UR) | TB deaths (95% UR) | QALYs (95% UR) |
| Status quo | $816,588 ($589,629–$1,144,728) | 18.88 (14.81–23.92) | 1.83 (1.12–3.30) | 14,963.00 (14,935.98–14,966.22) |
| Increased taxation | $800,890 ($579,868–$1,120,755) | 18.43 (14.53–23.30) | 1.76 (1.11–3.16) | 14,963.66 (14,937.19–14,966.72) |
| Pharmacotherapy and counselling | $955,921 ($726,763–$1,279,070) | 18.71 (14.71–23.68) | 1.80 (1.12–3.25) | 14,963.25 (14,936.45–14,966.41) |
| Pharmacotherapy, counselling, and mass media | $1,012,812 ($782,975–$1,333,469) | 18.62 (14.65–23.56) | 1.79 (1.11–3.22) | 14,963.40 (14,936.71–14,966.52) |
| All [taxation + mass media + pharmacotherapy + counselling] | $981,366 ($764,325–$1,283,894) | 17.72 (14.06–22.32) | 1.64 (1.03–2.93) | 14,964.76 (14,939.14–14,967.55) |
| Costs per person and ICERs—status quo as comparator | Incr. cost vs status quo | Incr. cost per TB case averted | Incr. cost per TB death averted | Incr. cost per QALY gained |
| Status quo [comparator] | – | – | – | – |
| Increased taxation | Saves $16 ($8 - $26) | Dominant | Dominant | Dominant |
| Pharmacotherapy and counselling | $142 ($125–$146) | $837,464 ($527,624–$1,462,565) | $4,990,117 ($2,495,571–$8,928,090) | $542,594 ($259,691–$812,827) |
| Pharmacotherapy, counselling, and mass media | $200 ($175–$206) | $760,387 ($478,141–$1,330,478) | $4,530,453 ($2,264,728–$8,115,767) | $492,482 ($235,705–$738,813) |
| All [taxation + mass media + pharmacotherapy + counselling] | $181 ($157–$196) | $142,907 ($78,263–$271,386) | $852,009 ($398,407–$1,594,941) | $93,717 ($41,304–$147,677) |
| ICERs per person—increased taxation as a comparator | Incr. cost vs Increased taxation | Incr. cost per TB case averted | Incr. cost per TB death averted | Incr. cost per QALY gained |
| Status quo | $16 ($8–$26) | Dominated | Dominated | Dominated |
| Increased taxation [comparator] | – | – | – | – |
| Pharmacotherapy and counselling | $155 ($139–$164) | Dominated | Dominated | Dominated |
| Pharmacotherapy, counselling, and mass media | $212 ($192–$222) | Dominated | Dominated | Dominated |
| All [taxation + mass media + pharmacotherapy + counselling] | $180 ($154–$195) | $256,022 ($151,962–$465,895) | $1,522,952 ($740,992–$2,789,202) | $164,369 ($76,252–$252,203) |
UR uncertainty range, ICER incremental cost-effectiveness ratio, Incr incremental
Numbers in parentheses represent 95% UR i.e. uncertainty ranges