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. 2019 Feb 4;20:24. doi: 10.1186/s13059-019-1638-y

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — The newly originated RNA editing events are selectively constrained in general. a For the newly originated polyAG editing sites with ancestral state of G, a site frequency spectrum for the derived A allele is shown (Editing Gain). As a background, a list of non-editing, homozygous A sites with ancestral state of G (Control) was used to generate a site frequency spectrum for derived A allele (“Methods”). b For the newly originated polyAG editing sites with ancestral state of A, a site frequency spectrum for the derived G allele is shown (Editing Loss). As a background, a list of non-editing, homozygous G sites with ancestral state of A (Control) was used to generate a site frequency spectrum for derived A allele (“Methods”)