Table 2.
Distribution of PrPCWD deposits in peripheral nerves, glands and organs of clinically affected and non-inoculated white-tailed deer
| Non-inoculated | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| wt/wt | ||||||||||||
| Genotype | wt/wt | S96/wt | H95/wt | H95/S96 | ||||||||
| D1 | D2 | D3 | D4 | D5 | D6 | D7 | D8 | D9 | D10 | D11 | D12 | |
| Optic nerve | ++ | + | ++ | + | + | + | / | + | + | ++ | / | – |
| Vagus nerve | ++ | + | + | / | / | + | – | + | – | + | – | – |
| Brachial plexus | / | – | – | / | / | – | – | / | / | – | – | – |
| Sciatic nerve | + | + | – | / | – | – | / | – | – | – | – | – |
| Pituitary gland | / | ++ | +++ | / | / | +++ | +++ | +++ | / | +++ | – | – |
| Islets of Langerhans | ++ | ++ | ++ | ++ | ++ | ++ | + | + | – | – | / | – |
| Adrenal Gl medulla | +++ | +++ | +++ | +++ | ++ | +++ | +++ | +++ | + | ++ | / | – |
| Ileoc. Valve villi/crypts | ++ | + | + | + | ++ | ++ | ++ | / | – | – | – | – |
| Kidney | ++a | + | + | + | + | / | + | + | – | – | – | – |
| Parotid salivary gland | + | + | – | / | + | + | – | + | – | / | / | – |
| Submandibular sal. Gl | / | + | – | / | + | + | + | + | – | – | / | – |
| Sublingual sal. Gl | / | – | – | / | / | – | – | – | – | – | / | – |
| Retina | +++ | +++ | +++ | + | +++ | +++ | + | +++ | ++ | ++ | / | – |
| Skeletal muscle | – | – | – | – | – | – | – | – | – | – | – | – |
| Heart | / | / | / | / | / | ++ | / | / | – | – | / | / |
| Lung | + a | – | – | – | – | – | – | – | – | – | – | – |
| Liver | – | – | – | – | – | – | – | – | – | – | – | – |
PrPCWD deposition was detected by IHC
aDeer showing inflammatory kidney disease and lung interstitial inflammation / Sample not available for evaluation