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. 2019 Feb 4;19:27. doi: 10.1186/s12890-019-0792-z

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — Histopathological changes of lung tissue in guinea pigs on days 14 and 28 after BLM administration. a H&E staining shows pulmonary inflammation, fibrosis, and integrity of the structure (original magnification× 20). b Masson’s staining shows deposition of collagens in lung tissues (original magnification× 20). c and d Degree of pulmonary fibrosis was evaluated by Ashcroft fibrotic scores and hydroxyproline (n = 6~7). *p < 0.05, ***p < 0.001 vs. PBS group