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. 2019 Feb;29(2):159–170. doi: 10.1101/gr.238444.118

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© 2019 Lord et al.; Published by Cold Spring Harbor Laboratory Press

This article, published in Genome Research, is available under a Creative Commons License (Attribution 4.0 International), as described at http://creativecommons.org/licenses/by/4.0/.

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Figure 4. — Selective constraint and pathogenicity scores. MAPS, with 95% CI, calculated for pathogenicity score brackets (least to most severe) in 13,750 unaffected parents from the DDD project, with Spearman's rank correlation coefficient.