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. 2019 Feb;29(2):184–192. doi: 10.1101/gr.238311.118

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© 2019 Shivram et al.; Published by Cold Spring Harbor Laboratory Press

This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first six months after the full-issue publication date (see http://genome.cshlp.org/site/misc/terms.xhtml). After six months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.

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Figure 2. — miRNA-repressed genes are enriched for PRC2 binding and H3K27me3. (A) miR-21 expression levels in response to VP55 induction. (Dox) doxycycline. (B) Volcano plot of differentially expressed miRNAs in response to VP55 induction. The x-axis represents log₂ fold difference between expression of miRNAs in VP55-induced and noninduced cells. The y-axis represents −log₂ P-value of the expression difference calculated using DESeq2. (C,D) Enrichment for H3K27me3 (C) and SUZ12 (D) at genes derepressed in miRNA-depleted cells (miRNA-repressed genes). Enrichments were calculated using Enrichr (Chen et al. 2013).