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. 2019 Feb;11(2):a032235. doi: 10.1101/cshperspect.a032235

Figure 3.

Figure 3.

Gene ontology (GO) term enrichment and gene size expansion in premature 3′-end cleavage and polyadenylation (PCPA) sensitive genes compared with non-PCPAed, up-regulated genes. The enrichment of the GO terms (Supek et al. 2011; Fang et al. 2016) for the top 50% of genes, ranked by fold change, in either non-PCPAed, up-regulated (A) or PCPAed, down-regulated (B) genes are shown. The gene size for all human genes in these functional categories, not just expressed in our samples, are shown as box plots (C) that were found enriched in either PCPAed genes (blue, median size 38 kb) or non-PCPAed, up-regulated genes (red, median size 23 kb). Density plots showing the gene size (D) of human gene orthologs among non-PCPAed, up-regulated genes and PCPAed genes in five metazoans. The sizes of non-PCPAed and up-regulated genes did not change across Drosophila melanogaster (median 3.5 kb), Takifugu rubripes (median 2.5 kb), Gallus gallus (median 4.3 kb), Mus musculus (median 5.9 kb), and Homo sapiens (median 6.8 kb); but PCPAed and down-regulated genes expanded significantly in these same species (medians 4.4 kb, 5.2 kb, 18.4 kb, 38 kb, and 45.0 kb, respectively).