. 2019 Feb;9(2):a031682. doi: 10.1101/cshperspect.a031682

Table 1.

Licensed monovalent hepatitis A virus vaccines manufactured in the United States, Europe, Japan, and China

Vaccine type	HAV strain	Trade name^a	Adjuvant	Administration (dosage)			Manufacturer(s)
Vaccine type	HAV strain	Trade name^a	Adjuvant	Route	Pediatric	Adult	Manufacturer(s)
Formaldehyde-inactivated	HM-175	HAVRIX	Alum hydroxide	i.m.	720 EU	1440 EU	GlaxoSmikthKline Biologicals
Formaldehyde-inactivated	CR-326	VAQTA	Alum hydroxide	i.m.	25 U	50 U	MerckVaccines
Formaldehyde-inactivated	GBM	AVAXIM	Alum hydroxide	i.m.	80 U	160 U	Sanofi-Pasteur
Formaldehyde-inactivated	RG-SB	EPAXAL^b	Virosome	i.m.	24 U	24 U	Crucell/Berna Biotech
Formaldehyde-inactivated	TZ-84	Healive	Alum hydroxide	i.m.	250 U	500 U	Sinovac Biotech
Formaldehyde-inactivated, freeze-dried	KRM003	Aimugen	Alum-free	i.m.	0.5 µg	0.5 µg	Chemo-Sero-Therapeutic Research Institute, Japan; Kaketsuken
Formaldehyde-inactivated	Lv-8	Weisairuian	Alum hydroxide	i.m.	320 EU	640 EU	Institute of Medical Biology, Chinese Academy of Medical Sciences
Formaldehyde-inactivated	YN-5	Veraxim	Alum hydroxide	i.m.	800 EU	1600 EU	Shanghai Wilson Bioengineering
Live attenuated, freeze-dried	H2	Weisairuiji Biovac-A Mevac-A	None	s.c.	6.5 log₁₀ CCID₅₀		Institute of Medical Biology, Chinese Academy of Medical Sciences; Zhejiang Pukang Biotechnology; Zhejiang Academy of Medical Sciences
Live attenuated, freeze-dried	LA-1	HAVAC	None	s.c.	6.5 log₁₀ CCID₅₀		Changchun Institute of Biological Products; Changchun Changsheng Life Sciences

Data modified and updated from Shouval (2010) and Cui et al. (2014).

Limited information is available for Hep-A-in-Vac: an inactivated HAV vaccine manufactured in Russia (Gorbunov et al. 1998).

i.m., intramuscular; s.c., subcutaneous.

^a Some vaccine preparations are sold under multiple brand names in different countries.

^b EPAXAL manufacture was discontinued in 2014.