Effect of HEASR on serum total protein, albumin and total bilirubin in normal female Wistar rats. SA: Subacute, SC: Subchronic, TP: Total protein, ALB: Albumin, TBIL: total bilirubin. Results are expressed as mean ± S.E.M. n: total number per group. n (SA) = 8, n (SC) = 12. Mortality: HEASR5 (8.3%, male), HEASR6 (16.67%, male), HEASR4 SC (8.3%, female), HEASR5 SC (16.7%, female) and HEASR6 SC (25%, female). *p < 0.05 or **p < 0.01 when compared with control (distilled water: DW, 10 mL/kg) group. HEASR4: 250 mg/kg, HEASR5: 500 mg/kg, HEASR6: 1000 mg/kg, HEASR: hydroethanolic extract of A. smeathmannii root.