(A) section of subacute treated female rat lung tissue show air filled alveolar spaces with minimal surrounding interstitial inflammation or congestion of (distilled water: DW, 10 mL/kg, p.o.) and HEASR4 (NA); HEASR5 and HEASR6 (moderate pulmonary inflammatory) (B) spleen shows lymphoid aggregates which form follicles are seen in control (DW, 10 mL/kg, p.o.), HEASR4 and HEASR5 (NA); HEASR6 (areas of surroundin g sinusoidal congestion are seen, Splenic Congestion) (C) section of tissue show mucosal lining and underlying submucosa devoid of inflammatory cell infiltrates with no mucosal ulceration in control (DW, 10 mL/kg, p.o.); HEASR4 and HEASR5 (NA); HEASR6 (mucosal erosion). NA: No Abnormality. HEASR = Hydroethanolic extract of A. smathmannii root (H & E stain, mag. × 400).