Table 1.
Subacute and Subchronic Effect of HEASR on haematological indices in normal male rats.
| Control SA | HEASR4 SA | HEASR5 SA | HEASR6 SA | Control SC | HEASR4 SC | HEASR5 SC | HEASR6 SC | |
|---|---|---|---|---|---|---|---|---|
| WBC | 5.50 ± 0.40 | 4.50 ± 1.20 | 4.87 ± 1.22 | 6.97 ± 2.28 | 5.60 ± 0.26 | 5.17 ± 0.22 | 5.97 ± 0.52 | 6.77 ± 0.76 |
| LYMPH | 2.75 ± 0.03 | 2.03 ± 0.67 | 1.43 ± 0.09* | 2.87 ± 0.78 | 0.57 ± 0.27 | 1.47 ± 0.62* | 0.77 ± 0.58 | 1.20 ± 0.81* |
| MID | 0.75 ± 0.26 | 0.63 ± 0.17 | 0.63 ± 0.87 | 0.67 ± 0.24 | 2.50 ± 0.21 | 2.50 ± 0.25 | 2.33 ± 0.35 | 3.13 ± 0.09 |
| GRAN | 2.00 ± 0.12 | 1.83 ± 0.67 | 1.80 ± 0.50 | 3.43 ± 1.36* | 2.53 ± 0.60 | 5.70 ± 4.68* | 2.87 ± 0.52 | 2.43 ± 0.32 |
| LYMPH% | 50.10 ± 2.94 | 44.80 ± 7.72 | 35.53 ± 3.36* | 43.50 ± 4.56 | 10.63 ± 1.67 | 28.77 ± 1.02* | 11.80 ± 1.07 | 16.27 ± 1.98* |
| MID% | 13.65 ± 3.72 | 14.87 ± 0.41 | 28.50 ± 1.29 | 19.50 ± 0.61 | 44.90 ± 4.73 | 48.47 ± 3.99 | 38.50 ± 4.56 | 47.57 ± 5.60 |
| GRAN% | 36.25 ± 0.78 | 40.33 ± 7.92 | 35.97 ± 4.69 | 47.00 ± 4.76 | 44.47 ± 2.70 | 22.77 ± 3.21* | 49.70 ± 1.98 | 36.17 ± 4.73 |
| HGB | 13.50 ± 0.23 | 13.10 ± 0.75 | 12.50 ± 0.45 | 13.20 ± 0.29 | 13.80 ± 0.31 | 13.80 ± 0.15 | 14.53 ± 0.62 | 14.10 ± 0.06 |
| RBC | 6.88 ± 0.20 | 6.41 ± 0.50 | 6.70 ± 0.30 | 6.65 ± 0.26 | 6.63 ± 0.35 | 6.15 ± 0.58 | 7.08 ± 0.71 | 6.85 ± 0.39 |
| HCT | 42.30 ± 0.17 | 40.40 ± 2.89 | 39.10 ± 2.22 | 40.87 ± 1.25 | 48.33 ± 2.09 | 44.73 ± 1.89 | 48.93 ± 4.14 | 47.67 ± 1.07 |
| MCV | 61.80 ± 2.08 | 63.47 ± 4.22 | 58.37 ± 0.81 | 61.60 ± 0.50 | 73.20 ± 3.03 | 73.67 ± 4.62 | 69.33 ± 1.45 | 75.90 ± 6.45 |
| MCH | 19.60 ± 0.23 | 20.50 ± 0.82 | 18.60 ± 0.21 | 19.80 ± 0.42 | 20.83 ± 0.78 | 22.77 ± 2.10 | 20.73 ± 1.36 | 22.33 ± 1.51 |
| MCHC | 31.85 ± 0.66 | 32.50 ± 0.93 | 32.00 ± 0.83 | 32.27 ± 0.41 | 28.57 ± 0.64 | 30.90 ± 0.98 | 29.87 ± 1.39 | 29.53 ± 0.54 |
| RDWCV | 16.25 ± 0.55 | 17.33 ± 0.49 | 15.87 ± 0.85 | 15.50 ± 1.40 | 17.27 ± 0.66 | 17.77 ± 0.33 | 17.13 ± 0.72 | 16.40 ± 0.46 |
| RDWSD | 34.20 ± 2.14 | 34.90 ± 1.55 | 31.90 ± 2.29 | 33.43 ± 1.89 | 39.33 ± 1.10 | 39.57 ± 0.27 | 38.33 ± 1.77 | 38.13 ± 0.23 |
| PLT | 742.50 ± 2.59 | 678.33 ± 5.90 | 568.00 ± 3.70* | 750.00 ± 3.87 | 831.33 ± 2.67 | 786.67 ± 6.64 | 889.33 ± 2.54 | 849.67 ± 4.34 |
| MPV | 8.00 ± 0.40 | 8.07 ± 0.17 | 7.40 ± 0.12 | 7.40 ± 0.15 | 9.30 ± 0.23 | 9.97 ± 0.58 | 9.33 ± 0.20 | 9.27 ± 0.27 |
| PDW | 15.20 ± 0.12 | 15.43 ± 0.12 | 15.70 ± 0.17 | 15.23 ± 0.15 | 15.80 ± 0.06 | 15.70 ± 0.10 | 15.67 ± 0.15 | 15.67 ± 0.03 |
| PCT | 0.59 ± 0.03 | 0.55 ± 0.04 | 0.42 ± 0.02* | 0.56 ± 0.04 | 0.55 ± 0.01 | 0.62 ± 0.04 | 0.48 ± 0.02 | 0.67 ± 0.01* |
SA: Subacute, SC: Subchronic. HEASR: Hydroethanolic extract of Acridocarpus smeathmannii root. HEASR4: 250 mg/kg; HEASR5: 500 mg/kg. HEASR6: 1000 mg/kg. Data are expressed as mean ± SEM. n (SA) = 8, n (SC) = 12. Mortality: HEASR5 (8.3%, male), HEASR6 (16.67%, male), HEASR4 SC (8.3%, female), HEASR5 SC (16.7%, female) and HEASR6 SC (25%, female). **p < 0.05 or **p < 0.001 when compared with control distilled water (10 mL/kg) group. WBC x 103 (/mL) White Blood cell, LYMPH x 103 (/mL) Lymphocyte, MID (%): Minimum Inhibitory Dilution, GRAN (%)`: Granulocytes, HGB (g/dL): Hemoglobin, RBC x 106 /mL: Red Blood Cell, HCT (%): Hematocrit, MCV (fL): Mean Corpuscular Volume, MCH (pg/dL): Mean Corpuscular Hemoglobin, MCHC (g/dL): Mean Corpuscular Hemoglobin Concentration, RDWCV (%): Red Blood Cell Volume Distribution Width-CV, RDWSD (%): Red Blood Cell Volume Distribution Width-SD, PLT: Platelet, MPV (fL): Mean Platelet Volume, PDW: Plate Volume Distribution Width, PCT (%): Plateletcrit.