Table 2.
Subacute and Subchronic Effect of HEASR on haematological indices in normal female rats.
| Control SA | HEASR4 SA | HEASR5 SA | HEASR6 SA | Control SC | HEASR4 SC | HEASR5 SC | HEASR6 SC | |
|---|---|---|---|---|---|---|---|---|
| WBC | 12.417 ± 0.15 | 12.98 ± 0.17 | 9.9.1 ± 0.21* | 6.19 ± 0.32* | 7.33 ± 1.74 | 4.27 ± 0.57* | 5.40 ± 0.10* | 4.23 ± 0.13* |
| LYMPH | 2.10 ± 0.40 | 5.07 ± 0.17* | 3.47 ± 0.69* | 4.23 ± 0.93* | 4.10 ± 0.06 | 2.10 ± 0.40* | 2.05 ± 0.22* | 1.90 ± 0.06* |
| MID | 3.21 ± 0.370 | 5.91 ± 0.17* | 4.25 ± 0.26 | 3.3 ± 0.29 | 1.30 ± 0.05 | 0.73 ± 0.09 | 0.90 ± 0.10 | 0.70 ± 0.06* |
| GRAN | 89.97 ± 9.72 | 61.60 ± 3.87 | 53.07 ± 3.14* | 24.63 ± 2.29* | 1.93 ± 0.34 | 1.43 ± 0.09 | 1.93 ± 0.20 | 1.63 ± 0.09 |
| LYMPH% | 14.71 ± 0.87 | 17.80 ± 3.58 | 13.67 ± 2.14 | 18.97 ± 1.49* | 55.40 ± 1.04 | 48.30 ± 0.61 | 47.60 ± 2.75 | 44.67 ± 1.52 |
| MID% | 25.93 ± 1.04 | 50.20 ± 2.75* | 44.67 ± 2.12* | 51.63 ± 2.99* | 17.33 ± 0.91 | 17.70 ± 0.36 | 16.07 ± 2.05 | 15.97 ± 0.43 |
| GRAN% | 72.60 ± 1.42 | 42.00 ± 2.20* | 51.67 ± 3.25 | 29.40 ± 2.88** | 26.60 ± 1.50 | 34.00 ± 0.61 | 36.33 ± 4.56* | 39.37 ± 1.09* |
| HGB | 9.20 ± 1.14 | 8.87 ± 0.99 | 7.17 ± 2.63 | 7.97 ± 1.43 | 13.83 ± 0.84 | 13.53 ± 0.12 | 13.67 ± 0.46 | 13.13 ± 0.28 |
| RBC | 1.54 ± 0.11 | 1.83 ± 0.20 | 1.76 ± 0.24 | 1.68 ± 0.65 | 6.96 ± 0.33 | 6.74 ± 0.11 | 7.02 ± 0.21 | 6.18 ± 0.13 |
| HCT | 22.73 ± 2.51 | 23.60 ± 2.80 | 19.13 ± 3.94* | 21.63 ± 4.84 | 44.30 ± 1.01 | 40.93 ± 0.27* | 43.10 ± 0.60 | 37.03 ± 0.84 |
| MCV | 157.90 ± 4.10 | 167.07 ± 4.08 | 165.50 ± 8.57 | 144.03 ± 2.04 | 63.80 ± 0.40 | 60.77 ± 0.52* | 61.57 ± 1.03 | 60.03 ± 0.39 |
| MCH | 63.57 ± 0.96 | 62.70 ± 2.19 | 62.50 ± 4.45 | 55.30 ± 1.29 | 19.80 ± 0.29 | 19.27 ± 0.42 | 19.40 ± 0.38 | 19.57 ± 0.19 |
| MCHC | 40.30 ± 0.80 | 37.60 ± 0.47 | 37.80 ± 1.17 | 37.53 ± 2.27 | 31.13 ± 0.43 | 31.80 ± 0.46 | 31.63 ± 0.74 | 32.73 ± 0.52 |
| RDWCV | 12.57 ± 1.15 | 10.67 ± 1.28 | 12.57 ± 0.58 | 12.70 ± 3.11 | 17.20 ± 0.44 | 16.73 ± 0.33 | 15.80 ± 0.95 | 14.60 ± 0.32 |
| RDWSD | 75.87 ± 7.37 | 78.37 ± 1.11 | 84.57 ± 4.75 | 57.23 ± 4.12 | 36.83 ± 0.91 | 33.90 ± 0.87 | 34.20 ± 1.97 | 29.67 ± 0.87 |
| PLT | 78.00 ± 2.50 | 50.67 ± 1.29 | 58.00 ± 5.51 | 231.33 ± 1.84 | 793.67 ± 1.26 | 882.00 ± 1.75 | 774.67 ± 1.48 | 746.00 ± 1.67 |
| MPV | 7.27 ± 0.15 | 6.90 ± 0.80 | 7.77 ± 0.52 | 8.03 ± 1.09 | 8.23 ± 0.19 | 7.77 ± 0.17 | 7.53 ± 0.33 | 7.73 ± 0.17 |
| PDW | 16.80 ± 0.21 | 16.93 ± 0.23 | 16.97 ± 0.26 | 16.53 ± 0.55 | 15.37 ± 0.03 | 15.43 ± 0.03 | 15.20 ± 0.15 | 15.50 ± 0.21 |
| PCT | 0.06 ± 0.01 | 0.03 ± 0.01 | 0.05 ± 0.01 | 0.02 ± 0.02** | 0.65 ± 0.01 | 0.48 ± 0.19 | 0.58 ± 0.05 | 0.57 ± 0.04 |
SA: Subacute, SC: Subchronic. HEASR: Hydroethanolic extract of Acridocarpus smeathmannii root. HEASR4: 250 mg/kg; HEASR5: 500 mg/kg. HEASR6: 1000 mg/kg. Data are expressed as mean ± SEM. n (SA) = 8, n (SC) = 12. Mortality: HEASR5 (8.3%, male), HEASR6 (16.67%, male), HEASR4 SC (8.3%, female), HEASR5 SC (16.7%, female) and HEASR6 SC (25%, female). **p < 0.05 or **p < 0.001 when compared with control distilled water (10 mL/kg) group. WBC x 103 (/mL) White Blood cell, LYMPH x 103 (/mL) Lymphocyte, MID (%): Minimum Inhibitory Dilution, GRAN (%)`: Granulocytes, HGB (g/dL): Hemoglobin, RBC x 106 /mL: Red Blood Cell, HCT (%): Hematocrit, MCV (fL): Mean Corpuscular Volume, MCH (pg/dL): Mean Corpuscular Hemoglobin, MCHC (g/dL): Mean Corpuscular Hemoglobin Concentration, RDWCV (%): Red Blood Cell Volume Distribution Width-CV, RDWSD (%): Red Blood Cell Volume Distribution Width-SD, PLT: Platelet, MPV (fL): Mean Platelet Volume, PDW: Plate Volume Distribution Width, PCT (%): Plateletcrit.