Table 3.
Effect of hydroethanolic root of Acridocarpus smeathmannii extract on body hormones and COX-2 in serum of normal and treated rats using enzyme-linked immunosorbent assays.
| Control | HEASR4 (250 mg/kg) | HEASR5 (500 mg/kg) | HEASR6 (1000 mg/kg) | |
|---|---|---|---|---|
| TSTx | 2.36 ± 0.07 | 4.36 ± 0.07* | 6.72 ± 0.03** | 10.48 ± 0.09** |
| LHx | 25.53 ± 1.20 | 31.12 ± 1.10 | 34.62 ± 1.61 | 35.66 ± 1.11* |
| FSHx | 351.05 ± 3.80 | 170.63 ± 3.21* | 204.90 ± 2.40* | 208.39 ± 3.50* |
| COX-2x | 2.316 ± 0.12 | 2.280 ± 0.13 | 2.856 ± 0.12 | 3.240 ± 0.20 |
| LHy | 17.48 ± 0.20 | 49.30 ± 0.40** | 20.63 ± 0.61 | 52.10 ± 0.20** |
| FSHy | 230.42 ± 1.53 | 490.72 ± 1.50* | 233.42 ± 1.24 | 237.42 ± 1.72 |
| OESTy | 79.25 ± 1.09 | 88.37 ± 0.54 | 80.50 ± 0.36 | 55.66 ± 0.18 |
| COX-2y | 3.216 ± 0.12 | 3.516 ± 0.12 | 4.14 ± 0.020 | 4.920 ± 0.16 |
HEASR: hydroethanolic extract of Acridocarpus smeathmannii root. Results are expressed as mean ± S.E.M. n = 6. Mortality: HEASR5 (8.3%, male), HEASR6 (16.67%, male), HEASR4 SC (8.3%, female), HEASR5 SC (16.7%, female) and HEASR6 SC (25%, female). *p < 0.05 or **p< 0.01 when compared with control distilled water group. “x” and “y” in superscripts represented “male” and “female” rats respectively. LH: Luteinizing hormone (mIU/L), FSH: Follicle stimulating hormone (ng/mL), ESTR: Estrogen (pg/mL), PROGES: Progesterone (ng/mL), COX−2: cyclooxygenase−2 (ng/mL).