Summary of findings 3. Mixed action antidepressant compared to placebo for cannabis dependence.
| Mixed action antidepressant compared to placebo for cannabis dependence | |||||
| Patient or population: cannabis dependence Setting: outpatient Intervention: mixed action antidepressant Comparison: placebo | |||||
| Outcomes | Anticipated absolute effects* (95% CI) | Relative effect (95% CI) | № of participants (studies) | Certainty of the evidence (GRADE) | |
| Risk with placebo | Risk with mixed action antidepressant | ||||
| Participants abstinent at end of treatment | Study population |
RR 0.82 (0.12 to 5.41) |
179 (2 RCTs) | ⊕⊕⊝⊝ Lowa,b | |
| 250 per 1000 | 205 per 1000 (30 to 1000) | ||||
| Participants experiencing adverse effects | Study population |
RR 0.93 (0.55 to 1.55) |
76 (1 RCT) | ⊕⊕⊝⊝ Lowc | |
| 450 per 1000 | 419 per 1000 (248 to 698) | ||||
| Participants withdrawn due to adverse effects | Study population |
RR 1.44 (0.11 to 18.90) |
179 (2 RCTs) | ⊕⊕⊝⊝ Lowa,b | |
| 11 per 1000 | 16 per 1000 (1 to 205) | ||||
| Completion of scheduled treatment | Study population |
RR 0.93 (0.71 to 1.21) |
169 (2 RCTs) | ⊕⊕⊝⊝ Lowc | |
| 573 per 1000 | 533 per 1000 (407 to 694) | ||||
| *The risk in the intervention group (and its 95% confidence interval) is based on the assumed risk in the comparison group and the relative effect of the intervention (and its 95% CI). CI: confidence interval; RCT: randomised controlled trial; RR: risk ratio. | |||||
| GRADE Working Group grades of evidence High certainty: we are very confident that the true effect lies close to that of the estimate of the effect. Moderate certainty: we are moderately confident in the effect estimate: the true effect is likely to be close to the estimate of the effect, but there is a possibility that it is substantially different. Low certainty: our confidence in the effect estimate is limited: the true effect may be substantially different from the estimate of the effect. Very low certainty: we have very little confidence in the effect estimate: the true effect is likely to be substantially different from the estimate of effect. | |||||
aDowngraded one level for inconsistency: significant heterogeneity between studies.
bDowngraded one level for imprecision: very few events and small group sizes.
cDowngraded two levels for imprecision: very few events and small group sizes.
cStudies differed in direction of effect without significant heterogeneity.