Comparison 2. Selective serotonin‐reuptake inhibitor (SSRI) antidepressant versus placebo.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Participants abstinent at end of treatment	2	128	Risk Ratio (M‐H, Random, 95% CI)	1.73 [0.61, 4.89]
2 Participants experiencing adverse effects	1	76	Risk Ratio (M‐H, Random, 95% CI)	0.76 [0.57, 1.02]
3 Participants withdrawn due to adverse effects	1	76	Risk Ratio (M‐H, Random, 95% CI)	1.71 [0.16, 18.04]
4 Completion of scheduled treatment	3	198	Risk Ratio (M‐H, Random, 95% CI)	0.79 [0.49, 1.27]