Aubrun 2008.

Study characteristics
Methods	Randomised, double‐blind, placebo control
Participants	N = 90, 100% women
Interventions	Pre‐incisional ketamine 0.15 mg/kg bolus IV + IV PCA ketamine 0.5 mg/bolus
Outcomes	Pain intensity (VAS). Analgesic consumption. AEs. Outcomes reported every 6 h up to 48 h
Surgery type	Major gynaecological operation
Group numbers after end of study (treatment/control)	45/45
Age of patient population (treatment/control)	50 ± 10 49 ± 12
Notes	Support provided by departmental sources
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Low risk	Random number table
Allocation concealment (selection bias)	Unclear risk	Allocation concealment method not described
Blinding of participants and personnel (performance bias) All outcomes	Low risk	Blinded personnel
Blinding of outcome assessment (detection bias) All outcomes	Low risk	Blinded personnel
Incomplete outcome data (attrition bias) All outcomes	High risk	12% was withdrawn
Selective reporting (reporting bias)	Low risk	Predefined outcomes reported
Size	High risk	45 participants per treatment arm