Jaksch 2002.

Study characteristics
Methods	Randomised, double‐blind, placebo‐control
Participants	N = 30, 50% women
Interventions	S‐ketamine 0.5 mg/kg bolus IV before incision + infusion 2 µg/kg/min until 2 h after emergence from anaesthesia
Outcomes	Pain intensity (VAS) and PCA morphine consumption reported at 1, 24, 48, 72 and 120 h postoperatively. Time to first request for analgesia
Surgery type	Elective arthroscopic anterior cruciate ligament repair
Group numbers after end of study (treatment/control)	15/15
Age of patient population (treatment/control)	30 ± 8 33 ± 7
Notes	No mention of sponsorship or funding
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	Randomisation not described
Allocation concealment (selection bias)	Low risk	Quote: "Envelopes containing identification of the preparation administered were available for emergencies"
Blinding of participants and personnel (performance bias) All outcomes	Low risk	Nurses not involved in the study prepared study solutions
Blinding of outcome assessment (detection bias) All outcomes	Unclear risk	Blinding not described
Incomplete outcome data (attrition bias) All outcomes	Low risk	No withdrawals
Selective reporting (reporting bias)	Low risk	Predefined outcomes reported
Size	High risk	15 participants per treatment arm