Fig. 1.

The topology-informed pruning (TIP) algorithm. a The input tractogram of a target fiber bundle is generated using the adequate density of seedings. b The tractogram is used to compute the density map (yellow color) for identifying voxels with low-track density (red color). c Tracts passing low-density voxels are eliminated from the tractogram. d The resulting tractogram from the TIP algorithm eliminates singular tracts that are likely to be false connections