Table 2.
Cohort characteristics
| Saline | wtAPC | 3K3A-APC | Statistics | ||||||
|---|---|---|---|---|---|---|---|---|---|
| C-section | Asphyxia | C-section | Asphyxia | C-section | Asphyxia | P Birth | P Treat | P Int | |
| Number of pups | 6 | 9 | 6 | 7 | 7 | 7 | |||
| Sex (M; F) | 4; 2 | 3; 6 | 3; 3 | 3; 4 | 3; 4 | 4; 3 | |||
| Birth weight (g) | 5.43 ± 0.70 | 4.73 ± 0.57 | 5.24 ± 0.22 | 4.75 ± 0.60 | 5.18 ± 0.30 | 4.76 ± 0.60 | < 0.01 | NS | NS |
| Postmortem BW (g) | 5.22 ± 0.69 | 4.30 ± 0.44 | 4.91 ± 0.30 | 3.93 ± 0.93 | 5.01 ± 0.29 | 4.50 ± 0.95 | < 0.001 | NS | NS |
| 24 h weight loss (%) | 4.02 ± 3.04 | 11.68 ± 4.76 | 6.34 ± 4.88 | 17.23 ± 9.21 | 3.23 ± 3.39 | 6.40 ± 9.23 | < 0.05 | < 0.001 | NS |
| Brain weight (mg) | 488.3 ± 36.9 | 432.6 ± 30.6 | 447.5 ± 33.1 | 411.9 ± 37.3 | 462.5 ± 37.7 | 452.1 ± 44.8 | < 0.001 | NS | NS |
| Brain/body weight | 0.09 ± 0.00 | 0.10 ± 0.01 | 0.09 ± 0.00 | 0.11 ± 0.15 | 0.09 ± 0.00 | 0.10 ± 0.02 | < 0.01 | NS | NS |
Values are mean ± SEM; n = 6–9/group. Statistical analysis, 2-way ANOVA with the 2 independent variables as birth mode (PBirth; control c-section vs intrapartum asphyxia) and drug administration (PTreat; saline, wtAPC, or 3K3A-APC). Significance, P ≤ 0.05