Table 3.

Risk factors for common late complications of allo-HSCT

Late complications	Risk factors
cGVHD	(a) Donor characteristics Matched sibling donor is better than matched unrelated donor and is in turn better than haplo-identical unmatched donor [15] Gender Males make better donors than previously pregnant females [16] (b) Graft source/characteristics Umbilical cord blood is associated with less risk due to immunological immaturity of T cells. [17, 18] PBSCT associated with higher risk than BMT [19] (c) Stem cells manipulation with T cell depleted better than T cell replete [20] (e) Cytomegalovirus status [21]
Secondary malignancies	(a) Prior therapy: chemotherapy/radiotherapy [22] (b) Conditioning regimen: myelo ablative/reduced intensity conditioning [22]
Organ toxicity	(a) Prior therapy: chemotherapy/radiotherapy [22]. (b) Conditioning regimen: myeloablative/reduced intensity conditioning [22] (c) Post-transplant immunosuppression with busulphan and methotrexate are risk factors for the development of BO [23]
Infertility	(a) Total body irradiation predisposes to infertility [22]