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Anticancer agents associated with increased levels of GST and resistance
| Substrates of GST |
| Chlorambucil |
| Melphalan |
| Nitrogen mustard |
| Phosphoramide mustard |
| Acrolein |
| Carmustine |
| Hydroxyalkenals |
| Ethacrynic acid |
| Steroids |
| Not characterized as substrates |
| Antimetabolites* |
| Antimicrotubule drugs* |
| Topoisomerase I & II inhibitors* |
| Bleomycin |
| Hepsulfam |
| Mitomycin C* |
| Adriamycin* |
| Cisplatin* |
| Carboplatin |
Require JNK activation for cytotoxicity
