Table 1.

Perifosine dosing schema

Day 1 loading dose (mg)		Day 2–21 maintenance dose (mg)
Cycle 1	Subsequent cycles	Cycle 1	Subsequent cycles
Level 1		Level 1
I(a) 300 × 1 dose	100	50	50
I(b) 150 × 2 doses	100
I(c) 100 × 3 doses	100
Level II		Level II
II(a) 600 × 1 dose	200	100	100
II(b) 300 × 2 doses	200
II(c) 200 × 3 doses	200
Level III		Level III
III(a) 900 × 1 dose	300	150	150
III(b) 450 × 2 doses	300
III(c) 300 × 3 doses	300
Level IV		Level IV
IV(a) 1,200 × 1 dose	400	200	200
IV(b) 600 × 2 doses	400
IV(c) 400 × 3 doses	400
Level V		Level V
V(a) 1,500 × 1 dose	1,000	250	250
V(b) 500 × 3 doses	1,000
V(c) 250 × 6 doses	1,000

In order to better tolerate the large number of capsules per dose (50 mg/pill), the indicated loading doses are divided in two parts and administered every 6 h on day 1