Figure 3.

Effect of dofetilide on ionic current. Dofetilide selectively blocks the rapid delayed rectifier potassium current I_Kr. The concentration is normalized with respect to the free plasma concentration of Dofetilde, C_max = 2.1 nM. The solid line represents the fitted Hill model, $\beta =C^h∕[I{C}_{50}^h+C^h]$, with h = 0.6 and IC₅₀ = 1.0 nM; the error bars represent the standard error mean (Crumb et al., 2016).