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. 2019 Feb 1;143(2):e20181489. doi: 10.1542/peds.2018-1489

FIGURE 4.

FIGURE 4

Heat map showing associations (and statistical significance) between early life bifidobacteria abundance and OPV vaccine responses measured at 15 weeks and 2 years of age determined with multiple regression analyses as described in Methods. Responses include the CD4 T-cell SI, the ALS assay for IgG at 15 weeks, plasma IgG and IgA at 2 years for the 3 strains of virus included in the vaccine, the IgG AI and IgA AI for all 3 strains at 2 years. Bifidobacteria abundance measures were as follows: (1) mean abundance of the genus Bifidobacterium measured at 6, 11, and 15 weeks and single measures made at 6 weeks for (2) the genus Bifidobacterium; (3) the most abundant species, B longum; (4) the most abundant of 2 subspecies, B longum subspecies infantis; (5) the second subspecies, B longum subspecies longum; and 2 minor species, (6) B breve and (7) B bifidum. s1, strain 1; s2, strain 2; s3, strain 3.