Table 1.
The mean scores for the Tri-dimensional Personality Questionnaire (TPQ) dimensions; novelty seeking (NS), harm avoidance (HA) and reward dependence (RD), between the DRD2 rs12364283 (A>G), DRD2 rs1076560 (C>A) and DRD4 rs1800955 (T>C) genotypes
| TPQ dimensions | DRD2 rs12364283 | P value | DRD2 rs1076560 | P value | DRD4 rs1800955 | P value | ||||||
| AA | AG | GG | CC | CA | AA | TT | CT | CC | ||||
| Junior | ||||||||||||
| N | (66) | (8) | (2) | (55) | (23) | (3) | (27) | (28) | (11) | |||
| NS | 15.7±4.4 (66) | 13.1±3.6 (8) | 13.5±6.4 (2) | 0.240 | 15.0±4.2 (54) | 16.1±4.9 (20) | 14.7±4.9 (3) | 0.589 | 16.8±3.8 (26) | 16.1±4.2 (26) | 14.1±5.0 (11) | 0.201 |
| HA | 11.3±5.8 (66) | 10.4±5.5 (8) | 11.5±5.0 (2) | 0.908 | 11.5±5.5 (52) | 11.0±5.7 (23) | 15.7±8.6 (3) | 0.442 | 11.0±5.4 (25) | 9.9±6.1 (28) | 12.6±4.6 (11) | 0.401 |
| RD† | 18.1±4.4 (66) | 15.9±4.4 (8) | 22.5±2.1 (2) | 0.079 | 17.7±4.3 (55) | 18.2±4.7 (20) | 18.7±3.2 (3) | 0.859 | 15.5±4.2 (24) | 20.4±3.6 (28) | 18.9±3.1 (11) | <0.001 (<0.001)* |
| RD1 | 2.8±1.0 (27) | 4.1±0.8 (30) | 3.3±1.0 (11) | <0.001 (<0.001)* | ||||||||
| RD2 | 5.6±2.1 (27) | 6.0±1.6 (28) | 6.1±2.0 (11) | 0.629 | ||||||||
| RD3 | 5.4±2.5 (24) | 7.6±2.2 (31) | 6.6±1.9 (11) |
0.003
(0.002)* |
||||||||
| RD4 | 2.0±1.1 (27) | 2.8±1.1 (31) | 2.9±1.1 (11) | 0.005 (0.002)* | ||||||||
| Senior | ||||||||||||
| N | (116) | (26) | (102) | (31) | (5) | (40) | (73) | (26) | ||||
| NS | 16.4±5.6 (113) | 14.6±4.0 (26) | – | 0.068 | 15.9±4.9 (100) | 16.6±6.5 (31) | 19.3±8.6 (4) | 0.405 | 15.9±4.7 (39) | 16.0±5.7 (72) | 17.2±5.2 (26) | 0.710 |
| HA | 10.0±6.0 (116) | 10.0±4.9 (25) | – | 0.864 | 10.7±6.0 (101) | 8.6±5.3 (31) | 8.0±2.6 (5) | 0.158 | 8.5±5.3 (40) | 10.6±6.4 (73) | 10.5±4.6 (26) | 0.170 |
| RD† | 19.0±4.2 (116) | 20.2±4.0 (25) | – | 0.208 | 19.0±4.2 (102) | 20.0±4.2 (30) | 21.6±2.7 (5) | 0.233 | 20.0±4.2 (40) | 18.4±3.9 (73) | 20.6±4.2 (26) | 0.030 (0.010)** |
| RD1 | 3.7±1.2 (42) | 3.5±1.1 (73) | 4.0±1.1 (27) | 0.122 | ||||||||
| RD2 | 6.3±1.4 (40) | 5.8±2.0 (76) | 6.7±1.6 (28) | 0.053 | ||||||||
| RD3 | 7.0±2.3 (41) | 6.5±2.4 (75) | 6.5±2.5 (26) | 0.499 | ||||||||
| RD4 | 3.1±1.3 (42) | 2.7±1.3 (76) | 3.2±1.3 (27) | 0.237 | ||||||||
The means±SD are presented with total number (N) of participants given in parentheses. Significant differences between genotypes are highlighted in bold (p<0.05, age-adjusted, generalised linear model).
*Post-hocp value:rs1800955 TT vsCC+CT. ** Post-hocp value:rs1800955 CT vsTT+CC.
†TheRD main dimension is significantly different, thus the RD subscales (RD1–RD4) are alsodisplayed.