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An N-2-nitrobenzyl group alters the toxicity of peptide 2. Toxicity of macrocyclic β-hairpin peptides towards SH-SY5Y cells as reflected in LDH release and MTT conversion assays. SH-SY5Y cells were incubated for 72 hours with 50 μM of the indicated peptide before performing the assay. Error bars represent standard deviations propagated from five replicate runs.
