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. Author manuscript; available in PMC: 2019 Feb 4.
Published in final edited form as: Mol Carcinog. 2017 Jan 13;56(5):1472–1483. doi: 10.1002/mc.22607

FIGURE 3.

FIGURE 3

PPARβ/δ decreases SOX2 expression independently of RARα-mediated pathway in human neuroblastoma cell lines. (A) Quantitative western blot analysis of RARα and SOX2 expression in cells in response to atRA treatment, or transiently transfected with pSG5-RARα plasmid and activated with atRA. (B) CYP26A1 mRNA expression in MigR1 and hPPARβ/δ cells or cells transiently overexpressing RARα after atRA treatment. (C) SOX2 mRNA expression in MigR1 and hPPARβ/δ cells or cells transiently over-expressing RARα following atRA treatment. MigR1: cells with integrated MigR1 control vector; hPPARβ/δ: cells over-expressing PPARβ/δ. Values represent the mean ± S.E.M. Values with different superscript letters are significantly different at P ≤ 0.05