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. 2019 Feb 4;14(2):e0211532. doi: 10.1371/journal.pone.0211532

Table 4. Multivariate analyses of increasing, stable, biphasic and decreasing symptom prevalence in men.

Age groups, years
25–29 30–39 40–49 50–59 60–69 70–79 80+ p*)
N 243 612 680 2263 2636 856 363
Increasing prevalence, %
Leg pain 11.9 20.0 24.7 21.0 24.2 24.5 41.4 <0.0001
Joint pain 11.9 17.8 20.4 20.1 25.2 19.7 20.8 <0.005
Impaired hearing 9.9 11.2 15.7 18.4 31.7 52.1 80.5 <0.0001
Eye problems 10.7 15.8 25.4 17.1 19.5 28.8 53.5 <0.0001
Breathlessness 9.1 9.5 13.2 12.6 15.6 20.7 33.1 <0.0001
Dizziness 13.6 16.1 14.4 10.1 11.7 13.4 32.4 <0.0001
Cries easily 6.2 6.3 6.5 7.7 8.5 8.9 11.1 <0.01
Constipation 2.1 3.9 4.7 5.0 6.0 9.1 17.9 <0.0001
Difficulty passing urine 0.01 1.2 3.2 5.8 12.2 12.8 17.7 <0.0001
Stable prevalence, %
Chest pain 13.6 19.1 16.0 13.6 12.5 13.0 15.7 0.09
Feeling cold 15.6 13.9 10.9 10.2 9.7 14.1 18.7 0.17
Biphasic prevalence, %
Exhaustion 24.7 40.0 36.0 18.7 9.9 4.6 6.2 <0.0001
Overweight 9.1 22.5 25.7 17.6 16.2 12.4 7.4 <0.0001
Sweating 10.7 10.8 9.5 13.6 10.5 9.5 9.0 <0.05
Nervousness 8.6 10.8 11.2 11.6 9.0 6.6 7.8 <0.0005
Loss of weight 5.3 4.3 2.6 2.6 4.4 5.4 10.4 <0.001
Decreasing prevalence %
Back pain 35.0 44.0 46.3 33.7 32.0 21.7 23.3 <0.0001
Melancholy 36.2 40.0 41.8 23.9 19.5 15.2 19.9 <0.0001
Difficulty relaxing 27.6 36.1 31.2 22.6 15.3 9.8 11.1 <0.0001
Irritability 39.9 52.0 40.9 22.6 16.5 12.1 10.8 <0.0001
Insomnia 21.8 25.9 28.5 22.2 21.9 16.2 19.8 <0.005
General fatigue 65.0 70.4 39.0 18.1 12.7 9.5 13.1 <0.0001
Restlessness 40.7 36.6 28.4 17.4 12.6 7.4 10.9 <0.001
Impaired concentration 25.5 29.9 30.6 17.0 12.1 7.6 11.8 <0.0001
Headache 58.0 50.7 37.2 16.9 9.2 5.8 4.8 <0.001
Cough 31.7 31.8 20.3 16.0 14.5 12.5 14.3 <0.0001
Abdominal pain 26.7 27.5 17.8 15.3 10.5 8.4 9.5 <0.0001
Diarrhea 18.5 16.8 15.1 14.0 8.9 5.1 5.5 <0.0001
Nausea 14.8 14.6 11.0 6.2 4.5 3.2 4.7 <0.0001
Poor appetite 8.2 6.3 4.8 3.5 3.3 2.8 4.7 <0.005

*) p values refer to trends across age after adjustment for the influence of the covariates examination year, education, BMI, marital status and smoking in logistic regression models. The percentages were computed based on odds ratios.