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. 2019 Feb 4;14(2):e0211644. doi: 10.1371/journal.pone.0211644

Fig 1. Effects of anticonvulsants on DNA synthesis of glioblastoma and brain metastasis low passage cell lines.

Fig 1

Glioblastoma cells (HROG02, HROG05, HROG15, HROG24) and brain metastasis cells (HROBL01, HROBML03 and HROBMC01) growing in 96-well half-area microplates were treated with (A, B) carbamazepine, (C, D) levetiracetam, (E, F) perampanel or (G, H) valproic acid as indicated for 48 h, before DNA synthesis was assessed with the BrdU incorporation assay. One hundred percent BrdU incorporation corresponds to cells cultured without anticonvulsant. Data are presented as mean ± SEM (n ≥ 12 separate cultures); *p<0.05 versus control cultures (Kruskal-Wallis test with post hoc Dunn’s test).