Table 2. Variability of immunohistochemical scores (n) for Col1, Col3, MMP-3 and MMP-13 of the AT micrographs between groups.
| Protein expression | Groups | ||||
|---|---|---|---|---|---|
| I | ID | IDL | IDE | IDEAL | |
| Col1 | |||||
| No expression | 0 | 4 | 1 | 0 | 0 |
| Weak expression | 0 | 0 | 3 | 3 | 0 |
| Moderate expression | 2 | 0 | 0 | 1 | 4 |
| Strong expression | 2 | 0 | 0 | 0 | 0 |
| Median IHC score (IQR) | 2.5 (2–3) | 0 (0–0) a | 1 (0.25–1) | 1 (1–1.75) | 2 (2–2) b |
| Col3 | |||||
| No expression | 0 | 0 | 0 | 0 | 1 |
| Weak expression | 1 | 1 | 2 | 0 | 3 |
| Moderate expression | 3 | 3 | 2 | 4 | 0 |
| Strong expression | 0 | 0 | 0 | 0 | 0 |
| Median IHC score (IQR) | 2 (1.25–2) | 2 (1.25–2) | 1.5 (1–2) | 2 (2–2) | 1 (0.25–1) d |
| MMP-3 | |||||
| No expression | 0 | 0 | 3 | 1 | 3 |
| Weak expression | 0 | 4 | 1 | 3 | 1 |
| Moderate expression | 4 | 0 | 0 | 0 | 0 |
| Strong expression | 0 | 0 | 0 | 0 | 0 |
| Median IHC score (IQR) | 2 (2–2) | 1 (1–1) | 0 (0–0.75) a | 1 (0.25–1) | 0 (0–0.75) a |
| MMP-13 | |||||
| No expression | 0 | 0 | 4 | 2 | 3 |
| Weak expression | 2 | 0 | 0 | 2 | 1 |
| Moderate expression | 2 | 4 | 0 | 0 | 0 |
| Strong expression | 0 | 0 | 0 | 0 | 0 |
| Median IHC score (IQR) | 1.5 (1–2) | 2 (2–2) | 0 (0–0) b | 0.5 (0–1) | 0 (0–0.75) |
I, injured (n = 4); ID, injured diabetic (n = 4); IDL, injured diabetic plus LPBM (n = 4); IDE, injured diabetic plus aerobic exercise (n = 4); IDEAL, injured diabetic plus aerobic exercise and LPBM (n = 4); IQR, interquartile range. (n = 4 per group).
aP < 0.05 vs I group
bP < 0.05 vs ID group
dP < 0.05 vs IDE group.