Table 2:
Univariate Associations of RA Participant Characteristics with Myocardial Flow Reserve (MFR) and Left Ventricular Mass Index (LVMI)
| Characteristics | MFR | LVMI | ||
|---|---|---|---|---|
| β | p | β | p | |
| Myocardial Blood Flow Reserve | n/a | n/a | −2.0586 | 0.014 |
| Age per year | −0.0090 | 0.16 | 0.1090 | 0.020 |
| Male vs. Female | −0.3970 | 0.06 | −0.0370 | 0.98 |
| Race/ethnicity | ||||
| Non-Hispanic white | ref | ref | ||
| Non-Hispanic black | 0.1470 | 0.55 | 4.0930 | 0.017 |
| Hispanic | −0.1540 | 0.42 | 4.9770 | <0.001 |
| Other | −0.9520 | 0.083 | 4.9650 | 0.18 |
| Ever smoking vs. never | 0.0400 | 0.82 | 0.9430 | 0.47 |
| Hypertension, yes v. no | −0.2630 | 0.13 | 3.2790 | 0.009 |
| Systolic Blood Pressure (mmHg) | −0.0043 | 0.38 | 0.1336 | <0.001 |
| Diastolic Blood Pressure (mmHg) | −0.0045 | 0.60 | 0.0455 | 0.47 |
| BMI, per kg/m2 | 0.0080 | 0.64 | 0.4050 | 0.001 |
| Diabetes, yes v. no | 0.1270 | 0.65 | 3.3960 | 0.10 |
| Total cholesterol, per mg/dL | 0.0020 | 0.32 | 0.0020 | 0.89 |
| LDL, per mg/dL | 0.0030 | 0.30 | 0.0160 | 0.43 |
| HDL, per mg/dL | −0.0200 | 0.50 | −0.1210 | 0.10 |
| log Triglycerides, per mg/dL | 0.3040 | 0.14 | 2.1600 | 0.17 |
| RA duration (square root), per year | 0.0130 | 0.81 | 0.4350 | 0.27 |
| RF or anti-CCP, yes v. no | −0.1780 | 0.36 | 3.2300 | 0.025 |
| Swollen Joint Count (0-42), per joint | −0.0020 | 0.86 | 0.2110 | 0.024 |
| Tender Joint Count (0-44), per joint | 0.0100 | 0.21 | 0.0910 | 0.13 |
| DAS28-CRP, per unit | 0.0770 | 0.28 | 1.0830 | 0.036 |
| log CRP, per mg/L | −0.0670 | 0.33 | 0.9270 | 0.06 |
| Median IL-6, per unit | −0.2710 | 0.12 | 2.33 | 0.072 |
| AM stiffness (square root), per min | −0.0240 | 0.30 | 0.2090 | 0.29 |
| HAQ, per unit | −0.0560 | 0.61 | 1.0300 | 0.20 |
| Biologic, yes v. no | ||||
| No biologic | ref | ref | ||
| TNF inhibitors | 0.3130 | 0.110 | −0.3060 | 0.83 |
| Non-TNF biologics | 0.2400 | 0.43 | 2.2300 | 0.32 |
| Methotrexate, yes v. no | −0.1721 | 0.34 | 0.5939 | 0.65 |
| Current prednisone, yes v. no | −0.2700 | 0.15 | 1.3090 | 0.34 |
| Current statin, yes v.no | 0.2344 | 0.29 | 1.6282 | 0.38 |
| Current ACE-inhibitor, yes v. no | 0.0054 | 0.98 | 4.3343 | 0.010 |
| Current beta-blocker, yes v. no | −0.2133 | 0.93 | 2.7045 | 0.18 |
| CAC score | ||||
| CAC score zero | ref | ref | ||
| CAC score 0-99 | −0.2590 | 0.28 | 2.0808 | 0.042 |
| CAC score ≥100 | −0.1010 | 0.64 | 3.8480 | |
Legend: Beta coefficients represent the average change in the MFR or LVMI per 1-unit higher value of the independent continuous variable of interest or for those with versus those without the independent dichotomous variable of interest., MFR: myocardial Blood Flow Reserve, LVMI: Left Ventricule Mass indexed for height2.73, SD: Standard Deviation, IQR: inter quantile range, RA: rheumatoid arthritis, RF: rheumatoid factor, CCP: cyclic citrullinated protein antibody, DAS: disease activity score, HAQ: health assessment questionnaire, AM: morning, CRP: C-reactive protein, IL-6: interleukin 6, CAC: coronary artery calcium.