Table 2.

Multivariate models for the Association of Frailty with Incident Fractures in HIV-infected and uninfected women

	Time to 1st Fracture aHR (95% CI)	P value	Time from 1st to 2nd Fracture aHR (95% CI)	P value
Frailty	1.71 (1.30 – 2.26)	0.0001	1.69 (1.09 – 2.62)	0.019
HIV infection	1.32 (1.02 – 1.70)	0.035	0.80 (0.51 – 1.26)	0.34
Age (per 10 year increase)	1.20 (1.06 – 1.36)	0.0037
Race/Ethnicity (ref=White)  Black  Hispanic/Other	0.67 (0.52 – 0.86) 0.53 (0.37 – 0.76)	0.002 0.0005
Current smoking	1.57 (1.17 – 2.10)	0.0026
Cocaine use ever	1.31 (1.02 – 1.69)	0.034
Opiate Use ever	1.59 (1.26 – 2.01)	0.0001
Post-menopausal			1.52 (1.02 – 2.27)	0.040

Abbreviations: aHR: adjusted Hazard Ratio; CI: Confidence Interval. Only variables that were independently significant at P< 0.05 in the multivariate model are shown. HIV status and frailty were forced into models. Variables listed in table were measured at index visit and considered in the multivariate model and eliminated if they did not meet stepwise selection criteria of p-value ≥0.05.