Table 3.

Multivariate Models for Frailty Components Associated with Incident Fractures in HIV-infected and Uninfected Women

	Time to 1^st Fracture aHR (95% CI)	P value	Time from 1^st to 2^nd Fracture aHR (95% CI)	P value
Components of Frailty Index
Exhaustion	1.60 (1.26 – 2.04)	0.0001	1.98 (1.34 – 2.93)	0.0007
Unintentional weight loss	1.44 (1.06 – 1.94)	0.019
Reduced grip strength	1.35 (1.06 – 1.72)	0.017
HIV infection	1.18 (0.91 – 1.54)	0.22	0.81 (0.52 – 1.26)	0.35
Age (per 10 year increase)	1.22 (1.07 – 1.39)	0.0025
Race/Ethnicity (ref= White) Black Hispanic/Other	0.67 (0.51 – 0.87) 0.57 (0.39 – 0.82)	0.003 0.003
Current smoking	1.48 (1.10 – 2.00)	0.0099
Opiate use ever	1.61(1.26 – 2.06)	0.0001
Postmenopausal			1.53 (1.03 – 2.28)	0.036

Abbreviations: aHR: adjusted Hazard Ratio; CI: Confidence Interval. Only variables that were independently significant at P< 0.05 in the multivariate model are shown. HIV status was forced into models. All other variables listed in table were measured at index visit and considered in the multivariate model and eliminated if they did not meet stepwise selection criteria of p-value ≥0.05.