Table 4.

Multivariate models for the Association of Frailty with Incident Fractures in HIV-infected Women Only

Variable	Time to 1st Fracture aHR (95% CI)	P value	Time from 1st to 2nd Fracture aHR (95% CI)	P value
Frailty	1.91 (1.41 – 2.58)	<0.0001	1.86 (1.15 – 3.01)	0.01
Race/Ethnicity (ref= White)  Black  Hispanic/Other	0.65 (0.49 – 0.86) 0.52 (0.34 – 0.78)	0.0027 0.0015
Current smoking	1.84 (1.32 – 2.56)	0.0003
Opioid use ever	1.94 (1.50 – 2.51)	<.0001
Undetectable HIV RNA viral load			0.49 (0.31 – 0.77)	0.002
Postmenopausal			1.84 (1.17 – 2.89)	0.008

Abbreviations: aHR: adjusted Hazard Ratio; CI: Confidence Interval. Only variables that were independently significant at P < 0.05 in the multivariate model are shown. Frailty was forced into models. All other variables listed in table were measured at index visit and considered in the multivariate model and eliminated if they did not meet stepwise selection criteria of p-value ≥0.05.