Table 5.

Multivariate Models for Frailty Components Associated with Incident Fractures in HIV-infected Women Only

Variable	Time to 1^st Fracture aHR (95% CI)	P value	Time from 1^st to 2^nd Fracture aHR (95% CI)	P value
Components of Frailty Index
Exhaustion	1.57 (1.20 – 2.07)	0.0012	2.22 (1.40 – 3.53)	0.0007
Unintentional weight loss	1.44 (1.03 – 2.01)	0.032
Reduced grip strength	1.36 (1.03 – 1.79)	0.028
Race/Ethnicity (ref= White) Black Hispanic/Other	0.65 (0.48 – 0.88) 0.56 (0.36 – 0.86)	0.0057 0.0076
Undetectable HIV RNA viral load			0.47 (0.29 – 0.74)	0.001
Current smoking	1.64 (1.16 – 2.31)	0.0055
Opioid use ever	1.86 (1.41 – 2.46)	<0.0001
Postmenopausal			1.78 (1.13 – 2.80)	0.012

Abbreviations: aHR: adjusted Hazard Ratio; CI: Confidence Interval. Only variables that were independently significant at P < 0.05 in the multivariate model are shown. All variables listed in table were measured at index visit and considered in the multivariate model and eliminated if they did not meet stepwise selection criteria of p-value ≥0.05.