Figure 2.

Somatic mutations detected by targeted sequencing of cell‐free DNA (cfDNA) and genomic DNA (gDNA) from tumor tissue. Mutated genes detected by targeted sequencing are shown in the left‐most column (arranged in descending order of the number of mutations). Numbers for each gene indicate the frequency of the mutant allele (%). MISSSENSE, missense mutation; NONSENSE, nonsense mutation; INDEL, insertion/deletion; SPLICING, splicing site mutation. A, Somatic mutations in plasma cfDNA and gDNA from cancer (n = 5). B, Somatic mutations of plasma cfDNA in 16 RCC patients with at least one mutation. Patient state at blood collection was classified as “Pretreatment without metastasis” (purple), “Pretreatment with metastasis” (green) and “Post‐treatment with metastasis or recurrence” (red). Right bar plot shows the number of samples