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. 2019 Jan 25;110(2):617–628. doi: 10.1111/cas.13906

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© 2018 The Authors. Cancer Science published by John Wiley & Sons Australia, Ltd on behalf of Japanese Cancer Association.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Cell‐free DNA (cfDNA) fragment sizes with mutations were often shorter than corresponding fragments of wild‐type alleles. For each mutation detected by next‐generation sequencing (NGS), cfDNA fragment sizes between 50 and 250 bp were extracted from binary alignment map files by integrative genomics viewer. MT, mutation; WT, wild‐type. *P < .05, **P < .01 (Wilcoxon test). Central line, mean; error bars, SD. A‐C, In case 10, SETD2 (A), BAP1 (B) and NF2 (C). D,E, In case 13, VHL (D) and TP53 (E). F‐J, In case 50, FPGT (F), VHL (G), BAP1 (H), TSC1 (I) and TP53 (J)