Table 2.

List of the predicted binding sites for the transcription factors known to control miR-21 expression occurring at miR-21 TSS. The genomic region corresponding to the large segment analysed for differential methylation in this work was used for the analysis using Promo software (Messeguer et al., 2002; Farré et al., 2003)

Factor name	Start position	End position	String	RE equally	RE query	mir-21 up regulation
NF-kappaB [T00590]	401	412	TGGGAAACTCGA	0.009	0.00704	(Yang et al., 2015)
HIF-1 [T01609]	605	613	ACGTGCCAC	0.0201	0.01428	(Liu et al., 2014)
HIF-1 [T01609]	600	608	CAGGCACGT	0.04019	0.0242	(Liu et al., 2014)
p53 [T00671]	745	751	CGCGCCC	0.10718	0.03485	(Papagiannakopoulos et al., 2008)
PPAR-alpha:RXR-alpha [T05221]	497	507	TTGCCCAAGTT	0.06782	0.05126	(Kida et al., 2011)
E2F-1 [T01542]	693	700	TGATCCGC	0.14737	0.06899	(Bhat-Nakshatri et al., 2009)
E2F-1 [T01542]	540	547	ACCTCCGC	0.20096	0.07366	(Bhat-Nakshatri et al., 2009)
E2F-1 [T01542]	697	704	CCGCCCGC	0.20096	0.07989	(Bhat-Nakshatri et al., 2009)
p53 [T00671]	696	702	TCCGCCC	0.21436	0.09784	(Papagiannakopoulos et al., 2008)
p53 [T00671]	496	502	GTTGCCC	0.21436	0.10711	(Papagiannakopoulos et al., 2008)
p53 [T00671]	803	809	GCTGCCC	0.21436	0.10711	(Papagiannakopoulos et al., 2008)
E2F-1 [T01542]	740	747	GCCACCGC	0.32153	0.14301	(Bhat-Nakshatri et al., 2009)
C/EBPbeta [T00581]	557	560	TCAA	6.85938	7.77501	(McClure et al., 2017)