Table 1.
Cytotoxicity of curcumin and its cyclohexanone analogs on PC3 cells
| Treatment | 10% FBS RPMI‐1640a | FBS‐free RPMI‐1640a | ||
|---|---|---|---|---|
| IC20 (μmol/L) | IC50 (μmol/L) | IC20 (μmol/L) | IC50 (μmol/L) | |
| Curcumin | 16.83 ± 0.76 | 34.33 ± 4.25 | >10.00 | >10 |
| 2A | 4.83 ± 1.04 | 9.00 ± 0.87 *** | 4.25 ± 0.35 | >10 |
| 2F | 4.33 ± 0.58 | 6.33 ± 0.76 *** | 3.75 ± 0.35 | >10 |
| 2I | >100 | >100 | >10.00 | >10 |
| 2J | 17.00 ± 1.41 | >100 | 1.00 ± 0.00 | >10 |
a
Determined by MTT assay, the values are presented as mean ± SD of three independent experiments.
***P < 0.001 vs curcumin.