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. Author manuscript; available in PMC: 2020 Feb 1.
Published in final edited form as: Curr Opin Neurobiol. 2018 Oct 23;54:120–126. doi: 10.1016/j.conb.2018.10.006

Figure 1.

Figure 1

Organization of Mushroom body circuit that encodes olfactory memories and modulates sleep

(A)Cartoon of MB lobes formed by axons of MB-intrinsic Kenyon cells (KCs). KC axons are subdivided into α/β lobe shown in blue, α’/β’ in magenta, and γ in orange. (Illustration adapted from [89])

(B)Schematic of MB circuitry. Axons of odor-coding KCs can be subdivided into tiled zones that are each innervated by a single type of dopaminergic reinforcement neuron and provide output to a single MB output neuron (MBONs). Olfactory memories are encoded within the strength of synapses between KCs and MBONs. Modulatory DPM neurons project throughout the MB lobes and their recurrent activation after learning is required for consolidation of recent memories. (Based on findings from [67,69,81]).