Table 3.
Cardiac autoantibodies (AAb) during DCCT and the risk for coronary artery calcification (CAC)
| Risk factor | CAC positive (%) (n=31) |
CAC negative (%) (n=114) |
95% CI | P value | |
|---|---|---|---|---|---|
| Univariable analysis: Specific AAb type |
Unadjusted odds ratio |
||||
| S2-MYH6 | 10 (32) | 5 (4) | 10.4 | 3.2–34.5 | <0.001 |
| FL-MYH6 | 10 (32) | 2 (2) | 26.7 | 5.5–130.5 | <0.001 |
| S2-MYH6 or FL-MYH6 | 16 (52) | 7 (6) | 16.3 | 5.8–46.1 | <0.001 |
| Univariable analysis: Number of AAb | |||||
| Only one AAb | 4 (13) | 14 (12) | 1.1 | 0.3–3.5 | 0.93 |
| ≥2 AAb | 13 (42) | 3 (3) | 26.7 | 6.9–103.1 | <0.001 |
| Multivariable analysis: Specific AAb type |
Adjusted odds ratio |
||||
| S2-MYH6 | 10 (32) | 5 (4) | 9.8 | 1.6–59.5 | 0.01 |
| FL-MYH6 | 10 (32) | 2 (2) | 86.1 | 5.7–1290.0 | 0.001 |
| Multivariable analysis: Number of AAb | |||||
| Only one AAb | 4 (13) | 14 (12) | 2.8 | 0.5–14.6 | 0.22 |
| ≥2 AAb | 13 (42) | 3 (3) | 60.1 | 8.8–410.0 | <0.001 |
Univariable analyses were conducted using logistic regression. Multivariable analyses were adjusted for age at visit prior to the CAC measurement, sex, smoking status, and hypertension at the end of DCCT. No significant effect of hyperlipidemia at the end of DCCT, or smoking and hypertension at visit prior to the CAC measurement during EDIC follow-up study was observed.