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. Author manuscript; available in PMC: 2020 Feb 1.
Published in final edited form as: Br J Haematol. 2018 Nov 8;184(4):578–593. doi: 10.1111/bjh.15669

Fig 1. Expression of MSC genes linked to adipocytes and angiogenesis was altered in whole-bone biopsies of MM patients with high-risk disease and in FLs.

Fig 1.

(A) Expression levels of probe sets differentially expressed in mesenchymal stem cells (MSCs) of paired biopsy samples (i.e., two samples from the same patient) from focal lesions (FLs) versus random bone marrow (RBM), and in patients with high-risk versus low-risk multiple myeloma (MM). The probe sets are listed based on a false discovery rate (FDR) < 0.1 and expression difference > or < log2 0.25 between the tested groups. Note, in samples from patients with MM, of several genes associated with adipocytes (e.g. IGFBP2, AKR1C3) were downregulated and genes associated with angiogenesis (e.g. COL4A1, HSPG2) were upregulated. (B) Mean expression of IGFBP2 and COL4A1 is shown for MM plasma cells (MM PC; negative control) and for biopsies from healthy donors (N BX, n = 68); from patients with smouldering MM (SMM BX, n = 52), low-risk MM (LR MM BX, n = 467), and high-risk MM (HR MM BX, n = 64); and from FLs (FL BX, n = 178). Note gradual changes in expression of these genes at different disease stages of MM. GEP: gene expression profiling;