Skip to main content
. Author manuscript; available in PMC: 2020 Feb 1.
Published in final edited form as: Br J Haematol. 2018 Nov 8;184(4):578–593. doi: 10.1111/bjh.15669

Fig 2. Individual bone marrow MSCs express MSC genes at heterogeneous levels that are influenced by MM.

Fig 2.

Expression (mean ± SEM) of indicated genes analysed in single mesenchymal stem cells (MSCs)from three healthy donors (n = 175) and three patients with multiple myeloma (MM; n = 162). (A) Proportion (%) of single MSCs expressing indicated genes. *Genes in which the differential proportion between the two groups is > 10%. (B) Adjusted mean delta Ct (ΔCt) for single MSCs from patients with MM versus those from healthy donors were calculated by subtracting ΔCt of each gene with the mean of ΔCt of total cells. Gene expression was highly variable in individual MSCs, and expression of only a few genes (e.g., MKI67, CDKN2A) was significantly different between the two groups. * p<0.05; ** p<0.01; *** p<0.002.