Table 3.
Physicochemical properties of the model drugs.
| Physicochemical property | CAR | CIN | R3040 |
|---|---|---|---|
| Solubility in F65 (mg/g) | 25±1 | 26±1 | 216±13 |
| Solubility in F55 (mg/g) | 42±3 | 25±15 | 205±7 |
| Solubility in F20 (mg/g) | 73±5 | 20±0 | 74±4 |
| Solubility in gastric medium (µg/mL) | 333±18 | 57±1 | 8±2 |
| Solubility in initial intestinal medium (µg/mL) | 669±29 | 84±3 | 34±4 |
| Aqueous solubility (µg/mL) | 3730 | 2031 | <132 |
| pKa | 7.930 | 1.9 and 7.4731 | Neutral32 |
| LogP | 3.830 | 5.831 | 10.4 |
| Particle size (diameter, µm)a | 23±0 | 50±1 | 10±0 |
a
Particle size of aqueous suspensions of CAR, CIN and R3040. Data are presented as mean±SD (n=3).