Table 1.
LMTK2 interactome.
| Interactors | Type of interaction | Function | Cell line | Reference |
|---|---|---|---|---|
| PP1 | Phosphorylation of PP1c-T320 | Inhibition of PP1c | HeLa, COS7 | Manser et al., 2012a,b; Wang and Brautigan, 2002 |
| Inh2 | Direct binding (dependent of PP1c) | Regulation of PP1c | HeLa, COS7 | Wang and Brautigan, 2002 |
| Cdk5/p35 | Phosphorylation of LMTK2-S1418 | Activation of LMTK2 | HeLa, CHO, rat cortical neurons, COS | Kesavapany et al., 2003; Manser et al., 2012b |
| GSK3-β | Mediated by PP1c | Inhibition of GSK3-β phosphorylation, leading to its activation | HeLa | Manser et al., 2012a |
| KLC2 | Mediated by GSK3-β | Decreases KLC2 phosphorylation and promotes binding to Smad2 | HeLa | Manser et al., 2012a |
| Myosin VI | Direct binding (no phosphorylation) | Regulation of endocytic trafficking pathway | HeLa | Chibalina et al., 2007; Inoue et al., 2008 |
| CFTR | Phosphorylation of CFTR-S737 | Regulation of CFTR endocytosis | Calu-3, CFBE41o− | Luz et al., 2014; Wang and Brautigan, 2006 |
| NGF | Phosphorylation of LMTK2 | Down-regulation of LMTK2 activity | PC12 | Kawa et al., 2004 |
| BCL2/BCL-xL | Indirect interaction (cell-type dependent) | Regulation of expression of anti- and pro-apoptotic proteins | HME, MCF10A, HCT116, DLD-1 | Conti et al., 2017 |
| BIM | Indirect interaction (cell-type dependent) | Regulation of expression of anti- and pro-apoptotic proteins | HME, MCF10A, HCT116, DLD-1 | Conti et al., 2017 |
| AR | Direct binding | Inhibition of AR transcriptional activity | LNCaP, Human prostate tissue, HEK293 | Shah and Bradbury, 2015b |
PP1, protein phosphatase 1; Inh2, inhibitor 2; Cdk5, cyclin-dependent kinase-5; GSK3-β, glycogen synthase kinase 3 beta; KLC2, kinesin-1 light chain 2; CFTR, cystic fibrosis transmembrane conductance regulator; NGF, nerve growth factor; BCL, B-cell lymphoma; BIM, Bcl-2-interacting mediator of cell death; AR, androgen receptor.