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. 2019 Jan 29;10:17. doi: 10.3389/fendo.2019.00017

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Copyright © 2019 Campo, Andreone, Ambao, Urrutia, Calandra and Rulli.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Schematic representation of FSH effect on Sertoli cell endocrine activity at different stages of maturation. (A) Immature Sertoli cell: arrows indicate the effects of recombinant human FSH (rhFSH) and basic charge analogs (BA-FSH) isolated at pH 5-7 on estradiol (E₂) and inhibin B production. (B) Sertoli cell at advanced stage of maturation: arrows indicate the effects of rhFSH, growth factors produced by germ cells (TGF-β, EGF, IGF-1), and FSH glycoforms bearing high-mannose and hybrid- type oligosaccharides (HY-FSH) on inhibin B production.