Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2019 Jan 29;10:75. doi: 10.3389/fimmu.2019.00075

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2019 Kim, Gu, Madison, Song, Norwood, Hill, Wu, Corry, Kheradmand and Diehl.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Increased lung IL-17A after CS exposure drives the systemic inflammation and neutrophilia in the lung and blood. IL-17A wildtype or knockout mice were exposed to air or smoke for 2 months. (A) Levels of pro-Th17 cytokine, IL-1β in the lung and IL-1β and IL-6 in the blood as determined by Luminex assay. (B) Frequencies of neutrophils (CD11b⁺Ly6G⁺ cells) in the lung and blood. Representative and pooled data obtained (mean ± SEM) from two independent experiments with 5–6 animals are shown. Kruskal-Wallis test with Dunn's multiple comparison was used to determine significance. ns, P > 0.05; ^*P ≤ 0.05; ^**P < 0.01. All mice are on the B6 background and were cohoused for 2 weeks before smoke exposure.