Figure 2.

MHC Class II variants in SSNS. Accumulated genetic evidence has identified MHC Class II variants as a central component to SSNS pathogenesis. Additional risk variants such as those reported in BTNL2 and PLCG2, and other rare risk variants (race or none race specific) are likely to be involved as well. Environmental factors such as infection, atopy, and food allergies likely contribute to disease through increased activation of immune system.